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This is an index of adverse event reports related to Alkeran (Melphalan). Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the adverse reaction. Or scroll down to view a sample of recent reports further on this page.
Our database includes reports from Jan 2007 to Dec 2007. The information is not vetted and should not be cosidered as verified clinical evidence.
All cases (97)
Cases resulting in a serious event (97)
Cases resulting in death (14)
Cases resulting in life threatening events (23)
Cases resulting in hospitalization (49)
Cases resulting in disability (7)
Cases resulting in other serious reactions (30)
Below is a sample of adverse event reports reports related to Alkeran (Melphalan). For a complete list and/or a specific selection of reports, please use the links in the index above.
Adverse event in receiving Alkeran (Melphalan)
Reported by a individual with unspecified qualification from France on 2007-10-31
Patient:
Adverse reactions / side effects: Drug Toxicity, Cardiac Failure
Adverse event resulted in: death
Suspect drug(s):
Alkeran
Dosage: oral
Administration route: Oral
Indication: Multiple Myeloma
Cyclophosphamide
Indication: Stem Cell Transplant
Dexamethasone
Dosage: oral
Administration route: Oral
Indication: Multiple Myeloma
Disodium Clodronate (Formulation Unknown) (Disodium Clodronate)
Dosage: oral
Administration route: Oral
Doxorubicin Hydrochloride
Dosage: intravenous infus
Indication: Multiple Myeloma
Granulocyte Col.stim.fact (Formulation Unknown) (Granulocyte Col.stim.
Mesna
Indication: Stem Cell Transplant
Stem Cell Transplant (Formulation Unknown) (Stem Cell Transplant)
Indication: Multiple Myeloma
Vincristine
Dosage: intravenous infus
Indication: Multiple Myeloma
Adverse event in receiving Alkeran (Melphalan)
Reported by a health professional (non-physician/pharmacist) from France on 2007-10-31
Patient:
Adverse reactions / side effects: Cerebrovascular Accident
Suspect drug(s):
Alkeran
Dosage: oral
Administration route: Oral
Indication: Multiple Myeloma
Thalidomide
Indication: Multiple Myeloma
Other drugs received by patient: Prednisone; Disodium Clodronate
Adverse event in 57 year old male receiving Alkeran (Melphalan)
Reported by a consumer/non-health professional from France on 2007-10-31
Patient: 57 year old male
Adverse reactions / side effects: Hyperthermia, Lung Neoplasm, Pancytopenia, Cholestasis, Cardiac Disorder, Liver Function Test Abnormal, Bone Marrow Failure, Hepatosplenomegaly, Oxygen Saturation Decreased
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Dosage: 280mg single dose
Start date: 2007-02-21
End date: 2007-02-21
Bicnu
Dosage: 600mg single dose
Start date: 2007-02-16
End date: 2007-02-16
Cytarabine
Dosage: 400mg twice per day
Start date: 2007-02-17
End date: 2007-02-20
Etoposide
Dosage: 400mg per day
Start date: 2007-02-17
End date: 2007-02-20
Kepivance
Dosage: 8mg per day
Start date: 2007-02-12
End date: 2007-02-25
Mabthera
Dosage: 500mg cumulative dose
Start date: 2007-02-08
End date: 2007-02-21
Zevalin
Dosage: 890mbq single dose
Start date: 2007-02-08
End date: 2007-02-08
Other drugs received by patient: Heparin; Zofran; Emend; Tazocilline; Fortum; Ciflox; Flagyl; Vancomycin; Caspofungin; Voriconazole; Ambisome; Zelitrex; Zovirax; Bactrim; Amiklin; Autograft OF Peripheral Blood Stem Cells; Granocyte; Tienam
Adverse event in receiving Alkeran (Melphalan)
Reported by a individual with unspecified qualification from France on 2007-10-31
Patient:
Adverse reactions / side effects: Drug Toxicity
Adverse event resulted in: death
Suspect drug(s):
Alkeran
Dosage: oral
Administration route: Oral
Indication: Multiple Myeloma
Cyclophosphamide
Indication: Stem Cell Transplant
Dexamethasone
Dosage: oral
Administration route: Oral
Indication: Multiple Myeloma
Disodium Clodronate (Formulation Unknown) (Disodium Clodronate)
Dosage: oral
Administration route: Oral
Doxorubicin HCL
Dosage: intravenous infus
Indication: Multiple Myeloma
Granulocyte Col.stim.fact (Formulation Unknown) (Granulocyte Col.stim.
Mesna
Indication: Stem Cell Transplant
Stem Cell Transplant (Formulation Unknown) (Stem Cell Transplant)
Vincristine
Dosage: intravenous infus
Indication: Multiple Myeloma
Adverse event in 39 year old male receiving Alkeran (Melphalan)
Reported by a individual with unspecified qualification from Japan on 2007-10-26
Patient: 39 year old male
Adverse reactions / side effects: Mechanical Ventilation, Status Epilepticus, Pyrexia, Disorientation, Rash, Convulsion, Pruritus Generalised, Encephalitis Herpes, Human Herpes Virus 6 Serology Positive, Memory Impairment, Altered State of Consciousness
Adverse event resulted in: life threatening event, disablity
Suspect drug(s):
Alkeran
Dosage: 135 g/d
Start date: 2007-01-15
End date: 2007-01-15
Fludara
Dosage: 42 g/d
Start date: 2007-01-10
End date: 2007-01-14
Foscarnet
Gleevec
Dosage: 800 mg/d
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
End date: 2007-01-15
Gleevec
Dosage: 600/d
Administration route: Oral
Start date: 2007-05-01
Other drugs received by patient: Diflucan; Urso 250; Zovirax; Denosine; Methotrexate; Tacrolimus
Adverse event in 39 year old male receiving Alkeran (Melphalan)
Reported by a individual with unspecified qualification from Japan on 2007-10-22
Patient: 39 year old male
Adverse reactions / side effects: Mechanical Ventilation, Encephalitis Herpes, Human Herpes Virus 6 Serology Positive, Memory Impairment, Pyrexia, Status Epilepticus, Altered State of Consciousness
Adverse event resulted in: life threatening event, disablity
Suspect drug(s):
Alkeran
Dosage: 135 g/d
Start date: 2007-01-15
End date: 2007-01-15
Fludara
Dosage: 42 g/d
Start date: 2007-01-10
End date: 2007-01-14
Gleevec
Dosage: 600 /d
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
End date: 2007-01-15
Gleevec
Dosage: 600/d
Administration route: Oral
Start date: 2007-05-01
Other drugs received by patient: Diflucan; Urso 250; Zovirax; Denosine
Adverse event in 63 year old male receiving Alkeran (Melphalan)
Reported by a physician from France on 2007-10-22
Patient: 63 year old male, weighing 65.0 kg (143.0 pounds)
Adverse reactions / side effects: Anaemia, Lung Infection, Rales, Disorientation, Pyrexia, Fall, Nervous System Disorder, Neutropenia, Leukopenia, Cough, Infection, Inflammation
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Dosage: 8.00 mg, oral
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-05-21
End date: 2007-09-13
Velcade
Dosage: 0.70 mg/m2, intravenous
Indication: Multiple Myeloma
Start date: 2007-05-21
End date: 2007-09-17
Adverse event in 57 year old female receiving Alkeran (Melphalan)
Reported by a physician from France on 2007-10-12
Patient: 57 year old female
Adverse reactions / side effects: Bone Marrow Failure
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Indication: Drug USE FOR Unknown Indication
CC-5013 (Lenalidomide) (Capsules)
Dosage: 25 mg, 21 days per month, oral; 25 mg, daily, oral
Administration route: Oral
Indication: Multiple Myeloma
End date: 2007-07-15
CC-5013 (Lenalidomide) (Capsules)
Dosage: 25 mg, 21 days per month, oral; 25 mg, daily, oral
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-08-30
End date: 2007-09-18
Other drugs received by patient: Dexamethasone TAB; Pamidronate Disodium
Adverse event in 51 year old male receiving Alkeran (Melphalan)
Reported by a physician from France on 2007-10-09
Patient: 51 year old male, weighing 73.0 kg (160.6 pounds)
Adverse reactions / side effects: C-Reactive Protein Increased, Febrile Bone Marrow Aplasia
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Indication: Multiple Myeloma
Start date: 2006-12-06
End date: 2006-12-06
Cisplatin
Indication: Multiple Myeloma
Cyclophosphamide
Indication: Multiple Myeloma
Dexamethasone
Indication: Multiple Myeloma
Doxorubicin HCL
Indication: Multiple Myeloma
Etoposide
Indication: Multiple Myeloma
Velcade
Indication: Multiple Myeloma
Adverse event in male receiving Alkeran (Melphalan)
Reported by a pharmacist from Japan on 2007-10-04
Patient: male, weighing 62.0 kg (136.4 pounds)
Adverse reactions / side effects: Interstitial Lung Disease, Angina Pectoris, Upper Respiratory Tract Inflammation, Headache, Pyrexia, Abdominal Pain Upper
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Alkeran (Melphalan)
Other drugs received by patient: Aspirin; Rabeprazole Sodium; Frandol S; Prednisolone
Adverse event in receiving Alkeran (Melphalan)
Reported by a pharmacist from United States on 2007-10-02
Patient:
Adverse reactions / side effects: Visual Disturbance
Suspect drug(s):
Alkeran (Melphalan)
Adverse event in 10 year old female receiving Alkeran (Melphalan)
Reported by a physician from Japan on 2007-07-31
Patient: 10 year old female, weighing 23.2 kg (51.0 pounds)
Adverse reactions / side effects: Photosensitivity Reaction, Bedridden, Toxic Encephalopathy, Muscular Weakness, Loss of Consciousness, Convulsion, Abdominal Pain Upper, Dysstasia, Fatigue, Vitreous Floaters, Dizziness
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Dosage: 55mg per day
Indication: Stem Cell Transplant
Start date: 2007-07-09
End date: 2007-07-11
Fludarabine Phosphate
Dosage: 20mg per day
Indication: Stem Cell Transplant
Start date: 2007-07-05
End date: 2007-07-08
Hydroxyzine Pamoate
Dosage: 20mg per day
Indication: Sedation
Start date: 2007-07-11
End date: 2007-07-11
Pentazocine Lactate
Dosage: 12mg per day
Indication: Sedation
Start date: 2007-07-11
End date: 2007-07-11
Zaditen
Dosage: .99mg three times per day
Administration route: Oral
Start date: 2007-06-30
End date: 2007-07-11
Other drugs received by patient: Baktar; Diflucan; Kytril; Heparin; Gamimune N 5%; Radiation; Chemotherapy; Unknown Drug
Adverse event in 10 year old female receiving Alkeran (Melphalan)
Reported by a physician from Japan on 2007-07-20
Patient: 10 year old female
Adverse reactions / side effects: Dizziness, Convulsion
Adverse event resulted in: hospitalization, disablity
Suspect drug(s):
Alkeran (Melphalan)
Other drugs received by patient: Fludarabine Phosphate; Zaditen; Baktar; Diflucan; Hydroxyzine Pamoate; Pentazocine Lactate
Adverse event in 81 year old female receiving Alkeran (Melphalan)
Reported by a physician from United States on 2007-07-13
Patient: 81 year old female, weighing 87.1 kg (191.6 pounds)
Adverse reactions / side effects: White Blood Cell Count Decreased, Fatigue, Oedema Peripheral, Platelet Count Decreased, Hypoaesthesia, Rash Maculo-Papular, Erythema, Rash Pruritic
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Indication: Multiple Myeloma
Start date: 2007-01-01
Revlimid
Dosage: see image
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2006-08-01
End date: 2007-04-17
Revlimid
Dosage: see image
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-04-24
End date: 2007-05-15
Other drugs received by patient: Allopurinol; Dexamethasone TAB; Aredia
Adverse event in 79 year old male receiving Alkeran (Melphalan)
Reported by a physician from United States on 2007-07-06
Patient: 79 year old male
Adverse reactions / side effects: Myocardial Infarction
Adverse event resulted in: death
Suspect drug(s):
Alkeran
Dosage: 2 mg, daily;
Indication: Multiple Myeloma
Start date: 2007-03-14
Revlimid
Dosage: 20 mg, 2 in1 d, oral
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-03-14
Adverse event in 75 year old female receiving Alkeran (Melphalan)
Reported by a physician from Germany on 2007-07-02
Patient: 75 year old female
Adverse reactions / side effects: Tooth Loss, Primary Sequestrum, Post Procedural Haematoma, X-RAY Abnormal, Dental Operation, Oedema Mouth, Blood Creatinine Increased, Cellulitis, Osteomyelitis Chronic, Osteitis, Operative Haemorrhage, Antibiotic Prophylaxis, Histology Abnormal, Osteonecrosis, Acute Sinusitis, Swelling, Disturbance in Attention, Nasal Operation, Actinomycosis, Plastic Surgery, Purulent Discharge, Biopsy, Dental Fistula, Sequestrectomy, General Anaesthesia, Depression, Bone Disorder, Blood Immunoglobulin A Increased, Gingival Ulceration, Gingival Swelling, Odontogenic Cyst, Amnesia, Haemoglobin Decreased, Osteotomy, Fibroma, Impaired Healing, Tumour Excision, JAW Disorder, Dental Alveolar Anomaly, Leukopenia
Adverse event resulted in: hospitalization
Suspect drug(s):
Acetylsalicylic Acid SRT
Dosage: 100 mg/day
Alkeran
Indication: Plasmacytoma
Start date: 2006-05-11
Alkeran
Start date: 2006-05-24
Alkeran
Start date: 2005-04-27
Alkeran
Start date: 2006-04-27
Alkeran
Start date: 2006-06-21
Alkeran
Start date: 2006-07-19
Cortisone Acetate
Zometa
Indication: Osteopenia
Start date: 2004-06-02
Zometa
Dosage: every 8 weeks
Start date: 2005-01-04
Zometa
Dosage: unk, qmo
Start date: 2005-08-16
End date: 2006-09-20
Other drugs received by patient: Fortecortin; Fortecortin; Fortecortin; Fortecortin; Arlevert; Magnesium Sulfate; Adalat; Isoket Retard; Diclofenac; Hydrochlorothiazide; Tramadol HCL; Metronidazole; Staphylex; Melphalan; Melphalan; Melphalan; Melphalan
Adverse event in 45 year old male receiving Alkeran (Melphalan)
Reported by a consumer/non-health professional from France on 2007-06-29
Patient: 45 year old male, weighing 112.0 kg (246.4 pounds)
Adverse reactions / side effects: Creatinine Renal Clearance Decreased, Proteinuria, Glomerulonephritis Acute, Blood Creatinine Increased, Renal Failure Acute
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran (Melphalan)
Other drugs received by patient: Zelitrex; Zofran; Neurontin; Bactrim DS; Speciafoldine; Omeprazole; Diantalvic; Dexamethasone 0.5mg TAB; Laroxyl; Fungizone; Gentamicin; Velcade; Cyclophosphamide; Dexamethasone 0.5mg TAB
Adverse event in 10 year old male receiving Alkeran (Melphalan)
Reported by a physician from Japan on 2007-06-26
Patient: 10 year old male, weighing 25.5 kg (56.1 pounds)
Adverse reactions / side effects: Stomatitis, Diarrhoea
Adverse event resulted in: disablity
Suspect drug(s):
Alkeran
Dosage: 70mg per day
Indication: Stem Cell Transplant
Start date: 2003-01-13
End date: 2003-01-19
Thiotepa
Dosage: 2mg per day
Indication: Stem Cell Transplant
Start date: 2003-01-13
End date: 2003-01-19
Other drugs received by patient: Neutrogin; Firstcin; Carbenin; Amikacin Sulfate; Diflucan; Zovirax; Fungizone; Baktar; Polymyxin B Sulfate; Florid
Adverse event in 79 year old male receiving Alkeran (Melphalan)
Reported by a individual with unspecified qualification from United States on 2007-06-25
Patient: 79 year old male
Adverse reactions / side effects: Myocardial Infarction
Adverse event resulted in: death
Suspect drug(s):
Alkeran
Dosage: 2 mg, daily
Indication: Multiple Myeloma
Start date: 2007-03-14
Revlimid
Dosage: 10 mg, 1 in 1 d, oral
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-03-14
Adverse event in 47 year old female receiving Alkeran (Melphalan)
Reported by a consumer/non-health professional from France on 2007-06-20
Patient: 47 year old female, weighing 55.0 kg (121.0 pounds)
Adverse reactions / side effects: Atelectasis, Dyspnoea, Lung Cyst Benign, Obstructive Airways Disorder, Lung Infiltration, Pulmonary Fibrosis
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Dosage: 230mg per day
Start date: 2001-01-26
End date: 2001-01-30
Myleran
Dosage: 8mg per day
Administration route: Oral
Start date: 2001-01-26
End date: 2001-01-30
Other drugs received by patient: Melphalan
Adverse event in 73 year old male receiving Alkeran (Melphalan)
Reported by a physician from United States on 2007-06-15
Patient: 73 year old male
Adverse reactions / side effects: Palpitations, Angina Pectoris, Heart Rate Irregular, Myocardial Infarction
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran
Dosage: 25 mg
Indication: Multiple Myeloma
Start date: 2007-04-27
Prednisone TAB
Dosage: 100 mg
Indication: Multiple Myeloma
Start date: 2007-04-27
Revlimid
Dosage: 10 mg, 1 in 1 d, oral
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-04-27
End date: 2007-05-06
Other drugs received by patient: Isosorbide Dinitrate
Adverse event in 72 year old male receiving Alkeran (Melphalan)
Reported by a consumer/non-health professional from Canada on 2007-06-04
Patient: 72 year old male
Adverse reactions / side effects: Blood Bilirubin Increased, Confusional State, Hepatic Function Abnormal, Acidosis, Fall, Somnolence, Hepatomegaly, Pulmonary Oedema, Hypoxia, Blood Creatinine Increased, Thrombocytopenia, Lethargy, Anaemia, Hypotension, Pancytopenia, Aggression, Cardiac Failure, Dehydration, Respiratory Arrest, Cardiac Arrest
Adverse event resulted in: death
Suspect drug(s):
Alkeran
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Prednisone TAB
Dosage: 125mg per day
Other drugs received by patient: Adalat; Atenolol; Colace; Dapsone; Dexamethasone; Docusate; Eprex; Gemfibrozil; Imovane; Lactulose; Lasix; Loperamide HCL; M-Eslon; Morphine; MS Contin; Oxygen; Percocet; RED Blood Cells; Risperdal; Senokot; Statex; Zopiclone
Adverse event in 74 year old male receiving Alkeran (Melphalan)
Reported by a individual with unspecified qualification from France on 2007-05-30
Patient: 74 year old male, weighing 75.0 kg (165.0 pounds)
Adverse reactions / side effects: Neurotoxicity, Chromosome Analysis Abnormal, Condition Aggravated, Myeloid Leukaemia, Multiple Myeloma
Adverse event resulted in: life threatening event
Suspect drug(s):
Alkeran
Dosage: 10.00 mg, unk, intravenous
Indication: Multiple Myeloma
Start date: 2004-04-01
End date: 2004-08-01
Cyclophosphamide
Indication: Multiple Myeloma
Start date: 2006-04-01
End date: 2006-06-01
Thalidomide
Indication: Multiple Myeloma
Start date: 2004-11-01
End date: 2005-01-01
Velcade
Dosage: 9.60 mg, unk, intravenous
Indication: Multiple Myeloma
Start date: 2005-10-10
End date: 2006-01-13
Adverse event in 75 year old male receiving Alkeran (Melphalan)
Reported by a physician from Japan on 2007-05-24
Patient: 75 year old male, weighing 53.0 kg (116.6 pounds)
Adverse reactions / side effects: Gastrointestinal Haemorrhage, Anaemia, Cystitis Haemorrhagic, Pyrexia, Urinary Bladder Haemorrhage
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Alkeran
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-03-05
End date: 2007-03-30
Predonine
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2007-03-05
End date: 2007-03-30
Other drugs received by patient: Onealfa; Allopurinol
Adverse event in 70 year old female receiving Alkeran (Melphalan)
Reported by a pharmacist from Japan on 2007-05-24
Patient: 70 year old female
Adverse reactions / side effects: White Blood Cell Count Decreased, Blood Potassium Decreased, Muscular Weakness
Adverse event resulted in: hospitalization
Suspect drug(s):
Alkeran (Melphalan)
Other drugs received by patient: Ranimustine; Vindesine Sulfate; Prednisolone; Zometa; Potassium Replacement
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