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This is an index of reports of adverse events (side effects, adverse reactions, etc.) related to Activase (Alteplase). Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the side effect / adverse reaction. Or scroll down to view a sample of recent reports further on this page.
Our database includes reports from Jan 2007 to Dec 2007. The information is not vetted and should not be cosidered as verified clinical evidence.
All cases (80)
Cases resulting in a serious event (76)
Cases resulting in death (39)
Cases resulting in life threatening events (8)
Cases resulting in hospitalization (21)
Cases resulting in disability (2)
Cases resulting in other serious reactions (18)
Below is a sample of reports where side effects / adverse reactions may be related to Activase (Alteplase). For a complete list and/or a specific selection of reports, please use the links in the index above.
Adverse event in 69 year old male receiving Activase (Alteplase)
Reported by a physician from Japan on 2007-10-19
Patient: 69 year old male
Adverse reactions / side effects: Cerebral Infarction, Epilepsy, Cerebral Haemorrhage
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Activase (Alteplase)
Other drugs received by patient: Aspirin; Radicut
Adverse event in 68 year old male receiving Activase (Alteplase)
Reported by a physician from Japan on 2007-10-17
Patient: 68 year old male
Adverse reactions / side effects: Renal Infarct
Adverse event resulted in: hospitalization
Suspect drug(s):
Activase (Alteplase)
Other drugs received by patient: Radicut; Zantac; Heparin; Unasyn; Nicardipine Hydrochloride
Adverse event in 71 year old male receiving Activase (Alteplase)
Reported by a health professional (non-physician/pharmacist) from Japan on 2007-10-17
Patient: 71 year old male
Adverse reactions / side effects: Abdominal Hernia
Adverse event resulted in: hospitalization
Suspect drug(s):
Activase (Alteplase)
Adverse event in female receiving Activase (Alteplase)
Reported by a consumer/non-health professional from United States on 2007-10-09
Patient: female
Adverse reactions / side effects: Compartment Syndrome
Suspect drug(s):
Activase
Dosage: 10 mg, unk
Indication: Vascular Graft Occlusion
Start date: 2007-09-05
Activase
Dosage: 0.5 mg/hr, continuous
Indication: Peripheral Ischaemia
Start date: 2007-09-05
Adverse event in 82 year old female receiving Activase (Alteplase)
Reported by a health professional (non-physician/pharmacist) from Japan on 2007-10-05
Patient: 82 year old female
Adverse reactions / side effects: Multi-Organ Failure, Disseminated Intravascular Coagulation
Adverse event resulted in: life threatening event
Suspect drug(s):
Activase
Dosage: 24 mg, unk
Indication: Cerebral Artery Embolism
Start date: 2007-06-09
End date: 2007-06-09
Radicut
Dosage: 30 mg, unk
Indication: Cerebral Artery Embolism
Start date: 2007-06-09
End date: 2007-06-09
Other drugs received by patient: Warfarin Potassium
Adverse event in 62 year old female receiving Activase (Alteplase)
Reported by a physician from Germany on 2007-10-05
Patient: 62 year old female
Adverse reactions / side effects: Retinal Haemorrhage, Drug Ineffective, Maculopathy
Suspect drug(s):
Activase (Alteplase)
Adverse event in 78 year old female receiving Activase (Alteplase)
Reported by a health professional (non-physician/pharmacist) from Germany on 2007-10-05
Patient: 78 year old female
Adverse reactions / side effects: Macular Hole
Suspect drug(s):
Activase (Alteplase)
Adverse event in 70 year old female receiving Activase (Alteplase)
Reported by a health professional (non-physician/pharmacist) from Germany on 2007-10-05
Patient: 70 year old female
Adverse reactions / side effects: Blindness Unilateral, Macular Hole
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a health professional (non-physician/pharmacist) from Germany on 2007-10-04
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in male receiving Activase (Alteplase)
Reported by a physician from Japan on 2007-10-01
Patient: male
Adverse reactions / side effects: Pancreatitis Acute
Adverse event resulted in: life threatening event
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a health professional (non-physician/pharmacist) from Germany on 2007-07-31
Patient:
Adverse reactions / side effects: Drug Ineffective, Amputation
Adverse event resulted in: disablity
Suspect drug(s):
Activase
Dosage: 3 mg/kg/h, 6 hours per day
Indication: Arterial Thrombosis
Heparin
Dosage: 10 u/kg/h, unk
Indication: Arterial Thrombosis
Adverse event in 80 year old male receiving Activase (Alteplase)
Reported by a physician from Japan on 2007-07-26
Patient: 80 year old male
Adverse reactions / side effects: Asthma, Atrial Fibrillation, Cerebral Haemorrhage
Suspect drug(s):
Activase (Alteplase)
Other drugs received by patient: Zantac 150; Deslanoside; LOW Molecular Dextran; Aminophylline; Lasix; Decadron; Heparin Sodium; Theo-DUR; Aspirin; Marzulene-S
Adverse event in 78 year old male receiving Activase (Alteplase)
Reported by a health professional (non-physician/pharmacist) from Germany on 2007-07-25
Patient: 78 year old male
Adverse reactions / side effects: Drug Ineffective, Septic Shock
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a consumer/non-health professional from Singapore on 2007-07-23
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a consumer/non-health professional from Singapore on 2007-07-23
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a physician from Singapore on 2007-07-23
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Activase (Alteplase)
Adverse event in 70 year old receiving Activase (Alteplase)
Reported by a physician from Singapore on 2007-07-23
Patient: 70 year old
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a physician from Korea, Republic of on 2007-07-23
Patient:
Adverse reactions / side effects: Death, Haemorrhage
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in female receiving Activase (Alteplase)
Reported by a physician from Singapore on 2007-07-23
Patient: female
Adverse reactions / side effects: Death, Condition Aggravated
Adverse event resulted in: death, hospitalization
Suspect drug(s):
Activase (Alteplase)
Adverse event in 74 year old female receiving Activase (Alteplase)
Reported by a physician from Japan on 2007-07-23
Patient: 74 year old female
Adverse reactions / side effects: Asthma, Tracheal Stenosis, Haemorrhagic Cerebral Infarction
Adverse event resulted in: death
Suspect drug(s):
Activase
Dosage: 36 mg/60 kg iv
Indication: Cerebral Artery Embolism
Start date: 2007-04-10
End date: 2007-04-10
Ticlopidine Hydrochloride
Administration route: Oral
Indication: Anticoagulant Therapy
Other drugs received by patient: Dextran 40-Lactated Ringer's Solution; Zantac 150; Radicut; Digoxin; Glyceol
Adverse event in receiving Activase (Alteplase)
Reported by a physician from Korea, Republic of on 2007-07-23
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a physician from Korea, Republic of on 2007-07-23
Patient:
Adverse reactions / side effects: Haemorrhage, Hemiplegia
Adverse event resulted in: hospitalization
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a consumer/non-health professional from Singapore on 2007-07-23
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Other drugs received by patient: Pharmaton
Adverse event in receiving Activase (Alteplase)
Reported by a physician from Korea, Republic of on 2007-07-23
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Adverse event in receiving Activase (Alteplase)
Reported by a physician from Singapore on 2007-07-23
Patient:
Adverse reactions / side effects: Death
Adverse event resulted in: death
Suspect drug(s):
Activase (Alteplase)
Other drugs received by patient: Pharmaton
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