Active ingredient: Zonisamide - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C8H8N2O3S

Chemical Name

benzo[d]isoxazol-3-ylmethanesulfonamide

Chemical Structure

Molecular Weight

212.227 g/mol

Physical State

Solid

Melting Point

161-163 oC

Water Solubility

0.8 mg/mL

Isoelectric Point

10.2

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target

Name	Voltage gated sodium channel
Gene Name	SCN1A
Synonyms	Sodium channel protein type I alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.1; Sodium channel protein, brain I alpha subunit
General Function	Inorganic ion transport and metabolism
Specific Function	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient