Brands, Medical Use, Clinical Data
Drug Category
- Antivirals
- Enzyme Inhibitors
- Neuraminidase Inhibitors
Dosage Forms
Brands / Synonyms
GANA; GNA; MODIFIED SIALIC ACID; Relenza; See Remark 8; Zanamavir
; ZMR
Indications
For the prevention and treatment of influenza
Pharmacology
Zanamivir, an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days.
Mechanism of Action
The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.
Absorption
4% to 17% following an orally inhaled dose
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not metabolized
Contraindications
RELENZA is contraindicated in patients with a known hypersensitivity to any component of the
formulation.
Drug Interactions
No clinically significant pharmacokinetic drug interactions are predicted based on data from in vitro
studies.
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