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Active ingredient: Vitamin D3 (Cholecalciferol) - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

3-[2-[7a-methyl-1-(6-methylheptan-2-yl)-2,3,3a,5,6,7-hexahydro-1H-inden-4- ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol

Chemical Structure

Molecular Weight

384.638 g/mol

Physical State


Melting Point

84.5 oC

Water Solubility


Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Cytochrome P450 24A1

Primary Drug Target
NameCytochrome P450 27
Gene NameCYP27A1
SynonymsCytochrome P450 27, mitochondrial precursor; EC 1.14.-.-; Cytochrome P-450C27/25; Sterol 26-hydroxylase; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
General FunctionSecondary metabolites biosynthesis, transport and catabolism
Specific FunctionCatalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity

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