Brands, Medical Use, Clinical Data
Drug Category
- Antioxidants
- Essential Vitamins
- Free Radical Scavengers
- Vitamins (Vitamin C)
Dosage Forms
- Capsule
- Tablet (chewable)
- Tablet (immediate release)
- Tablet (extended release)
- Lozenge
- Solution
- Parenteral injection
Brands / Synonyms
AA; Adenex; Allercorb; Antiscorbic Vitamin; Antiscorbutic Vitamin; Arco-Cee; Ascoltin; Ascor-B.I.D.; Ascorb; Ascorbajen; Ascorbate; Ascorbic Acid; Ascorbicab; Ascorbicap; Ascorbicin; Ascorbin; Ascorbutina; Ascorin; Ascorteal; Ascorvit; C-Level; C-Long; C-Quin; C-Span; C-Vimin; Cantan; Cantaxin; Catavin C; Ce Lent; Cebicure; Cebid; Cebion; Cebione; Cecon; Cee-Caps Td; Cee-Vite; Cegiolan; Ceglion; Celaskon; Celin; Cemagyl; Cemill; Cenetone; Cenolate; Cereon; Cergona; Cescorbat; Cetamid; Cetane; Cetane-Caps Tc; Cetane-Caps Td; Cetebe; Cetemican; Cevalin; Cevatine; Cevex; Cevi-Bid; Cevimin; Cevital; Cevitamic Acid; Cevitamin; Cevitan; Cevitex; Cewin; Ciamin; Cipca; Citriscorb; Colascor; Component of Chromagen; Component of Cortalex; Component of E and C-Level; Component of Endoglobin Forte; Component of Ferancee; Component of Freancee; Component of Stuartinic; Component of Tolfrinic; Component of Veliten; Concemin; Davitamon C; Duoscorb; Ferrous Ascorbate; Hicee; Hybrin; IDO-C; Iron-Ascorbic Acid Complexes; Kyselina Askorbova; L-Ascorbate; L-Ascorbic Acid; L-Ascorbic Acid Extra Pure; L-Lyxoascorbic Acid; L-Xyloascorbic Acid; Laroscorbine; Lemascorb; Liqui-Cee; Mediatric Component Of; Meri-C; Natrascorb; Natrascorb Injectable; Planavit C; Proscorbin; Redoxon; Ribena; Roscorbic; Scorbacid; Scorbu-C; Secorbate; Sodascorbate; Testascorbic; Vicelat; Vicin; Vicomin C; Viforcit; Viscorin; Vitace; Vitacee; Vitacimin; Vitacin; Vitamin C; Vitamisin; Vitascorbol; Xitix
Indications
Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
Pharmacology
Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency.
Mechanism of Action
In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.
Absorption
70% to 90%
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Hepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.
Contraindications
There are no contraindications to the administration of ascorbic acid.
Drug Interactions
Limited evidence suggests that ascorbic acid may influence the intensity and duration of action of
bishydroxycoumarin.
|
