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Active ingredient: Verapamil - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1- methylethyl)pentanenitrile

Chemical Structure

Molecular Weight

454.602 g/mol

Physical State


Melting Point

< 25 oC

Water Solubility

4.47 mg/L

Isoelectric Point


Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
NameVoltage-gated sodium channel
Gene NameSCN5A
SynonymsSodium channel protein type V alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.5; Sodium channel protein, cardiac muscle alpha-subunit; HH1
Specific FunctionThis protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram

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