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Active ingredient: Valproic Acid - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

2-propylpentanoic acid

Chemical Structure

Molecular Weight

144.211 g/mol

Physical State


Melting Point

120 - 130 oC

Water Solubility

Slightly soluble (1.3 mg/mL)

Isoelectric Point


Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
Name4-aminobutyrate aminotransferase, mitochondrial [Precursor]
Gene NameABAT
SynonymsEC; (S)-3-amino-2-methylpropionate transaminase; EC; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA aminotransferase; GABA-AT; GABA-T; L-AIBAT
General FunctionAmino acid transport and metabolism
Specific FunctionCatalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine
Pathwaymap00280 Valine, leucine and isoleucine degradation
Reaction(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

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