Active ingredient: Valproic Acid - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C8H16O2

Chemical Name

2-propylpentanoic acid

Chemical Structure

Molecular Weight

144.211 g/mol

Physical State

Solid

Melting Point

120 - 130 oC

Water Solubility

Slightly soluble (1.3 mg/mL)

Isoelectric Point

4.8

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	4-aminobutyrate aminotransferase, mitochondrial [Precursor]
Gene Name	ABAT
Synonyms	EC 2.6.1.19; (S)-3-amino-2-methylpropionate transaminase; EC 2.6.1.22; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA aminotransferase; GABA-AT; GABA-T; L-AIBAT
General Function	Amino acid transport and metabolism
Specific Function	Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine
Pathway	map00280 Valine, leucine and isoleucine degradation
Reaction	(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate