Chemisty and Biological Activity
Chemical Formula
C1376H2145N383O406S18
Chemical Name
Human urokinase
Chemical Structure
KPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSV
TYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFE
VENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYN
DPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEV
TTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDK
PGVYTRVSHFLPWIRSHTKEENGLAL
Molecular Weight
31126.5
Physical State
Liquid
Melting Point
76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).
Water Solubility
Not Available
Isoelectric Point
8.66
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | Plasminogen | | Gene Name | PLAUR | | Synonyms | Urokinase plasminogen activator surface receptor precursor; uPAR; U- PAR; Monocyte activation antigen Mo3; CD87 antigen | | Specific Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form |
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