Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
- Powder for solution
- Solution (IV infusion)
Brands / Synonyms
Abbokinase; Abbokinase (Abbott Laboratories)
; Kinlytic; U-plasminogen activator; uPA; Urokinase-type plasminogen activator precursor
Description
Low molecular weight form of human urokinase, that consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Recombinant urokinase plasminogen activator
Indications
For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance
Pharmacology
Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.
Mechanism of Action
Urokinase acts on the endogenous fibrinolytic system. It cleaves the Arg-Val bond in plasminogen to produce active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Proteolysis
Contraindications
Not Available
Drug Interactions
Not Available
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