Brands, Medical Use, Clinical Data
Brands / Synonyms
Bravelle; Fertinex (Serono S.A.)
; Follicle-stimulating hormone beta subunit; Follitropin beta chain precursor; FSH-B; FSH-beta
Human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the - and - subunits. The - and - subunits have 92 and 111 amino acids
For treatment of female infertility
Used for the treatment of female infertility, urofollitropin or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of urofollitropin is the primary hormone responsible for follicular recruitment and development.
Mechanism of Action
FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
Biotrnasformation / Drug Metabolism