Active ingredient: Uracil Mustard - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

• Antineoplastic Agents

Dosage Forms

• Not Available

Brands / Synonyms

Aminouracil Mustard; Chlorethaminacil; Demethyldopan; Desmethyldopan; Haemanthamine; Nordopan; Uracil nitrogen mustard; Uracillost; Uracilmostaza; Uramustin; Uramustine

Indications

Used for its antineoplastic properties.

Pharmacology

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

Mechanism of Action

After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available