Active ingredient: Trilostane - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C20H27NO3

Chemical Name

Not Available

Chemical Structure

Molecular Weight

329.433 g/mol

Physical State

Solid

Melting Point

264 oC

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
Gene Name	HSD3B1
Synonyms	3Beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- delta(5-steroid dehydrogenase; EC 1.1.1.145; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid delta- isomerase; EC 5.3.3.1; Delta-5-3-ketosteroid isomerase]
General Function	Cell wall/membrane/envelope biogenesis
Specific Function	3beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids
Pathway	map00140 C21-Steroid hormone metabolism map00150 Androgen and estrogen metabolism
Reaction	A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid