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Active ingredient: Trazodone - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C19H22ClN5O

Chemical Name

8-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-6,8,9- triazabicyclo[4.3.0]nona-2,4,9-trien-7-one

Chemical Structure

Molecular Weight

371.864 g/mol

Physical State

Solid

Melting Point

86-87 oC

Water Solubility

Sparigly soluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2D6

Primary Drug Target
Name5-HT-2A Receptor
Gene NameHTR2A
Synonyms5-hydroxytryptamine 2A receptor; 5-HT-2A; Serotonin receptor 2A; 5- HT-2
General FunctionReceptor activity and cell communication
Specific FunctionThis is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

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