Basic Profile / Key Facts
Drug Category
Dosage Forms
- Aerosol (with Propellants)
- Cream
- Gel
- Liquid
- Powder
- Spray
- Swab
Description
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, and Ting.
Indications
Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
Pharmacology
Tolnaftate is a synthetic over-the-counter anti-fungal agent.
Mechanism of Action
Topical - Fungicidal; exact mechanism unknown; however, it has been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Absorption
Not Available
Toxicity
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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