Brands, Medical Use, Clinical Data
- Vasodilator Agents
- Antihypertensive Agents
Brands / Synonyms
Artonil; Benzazoline; Benzidazol; Benzolin; Benzylimidazoline; Dilatol Asi; Divascol; Imidalin; Imidaline; Kasimid; Lambril; None; Olitensol; Peripherine; Phenylmethylimidazoline; Prefaxil; Priscol; Priscoline; Tolazolin; Vasimid; Vasodil; Vasodilatan
For the treatment of pulmonary artery anomalies
Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).
Mechanism of Action
Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.
Biotrnasformation / Drug Metabolism