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Active ingredient: Tigecycline - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C29H39N5O8

Chemical Name

N-[(5aR,6aS,7S,9Z,10aS)-9-(amino-hydroxy-methylidene)-4,7- bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro- 5H-tetracen-2-yl]-2-(tert-butylamino)acetamide

Chemical Structure

Molecular Weight

585.649 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Enteric bacteria and other eubacteria

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
Name30S ribosomal protein S4 - Escherichia coli
Gene NamerpsD
Synonyms30S ribosomal protein S4
General FunctionTranslation, ribosomal structure and biogenesis
Specific FunctionAlso functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase

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