Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
- Tablets (500 mg chewable)
- Suspension (containing 500 mg thiabendazole per 5 mL)
Brands / Synonyms
Apl-Luster; Arbotect; Bioguard; Bovizole; Chemviron TK 100; Cropasal; Drawipas; Eprofil; Equivet TZ; Equizole; Hokustar hp; Hymush; Lombristop; Mertec; Mertect; Mertect 160; Mertect 340f; Mertect lsp; Metasol TK 10; Metasol TK 100; Mintesol; Mintezol; Minzolum; Mycozol; Nemacin; Nemapan; Omnizole; Ormogal; Polival; RPH; Sanaizol 100; Sistesan; Storite; TBDZ; TBZ; TBZ 6; TBZ 60W; Tebuzate; Tecto; Tecto 10P; Tecto 40F; Tecto 60; Tecto B; Tecto rph; Testo; Thiaben; Thiabendazol; Thiabendole; Thiabenzazole; Thiabenzole; Thibendole; Thibenzol; Thibenzole; Thibenzole 200; Thibenzole att; Thiprazole; Tiabenda; Tiabendazol; Tiabendazole; Tibimix 20; Tobaz; Top form wormer; Triasox; Tubazole
Indications
For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
Pharmacology
Thiabendazole is a fungicide and parasiticide. Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Thiabendazole is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Thiabendazole also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.
Mechanism of Action
The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
Absorption
Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.
Toxicity
Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.
Biotrnasformation / Drug Metabolism
Hepatic. Metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates.
Contraindications
Hypersensitivity to this product.
Thiabendazole is contraindicated as prophylactic treatment for pinworm infestation.
Drug Interactions
Thiabendazole may compete with other drugs, such as theophylline, for sites of metabolism in the liver, thus
elevating the serum levels of such compounds to potentially toxic levels. Therefore, when concomitant use of
thiabendazole and xanthine derivatives is anticipated, it may be necessary to monitor blood levels and/or reduce the
dosage of such compounds. Such concomitant use should be administered under careful medical supervision.
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