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Active ingredient: Thiabendazole - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antinematodal Agents

Dosage Forms

  • Tablets (500 mg chewable)
  • Suspension (containing 500 mg thiabendazole per 5 mL)

Brands / Synonyms

Apl-Luster; Arbotect; Bioguard; Bovizole; Chemviron TK 100; Cropasal; Drawipas; Eprofil; Equivet TZ; Equizole; Hokustar hp; Hymush; Lombristop; Mertec; Mertect; Mertect 160; Mertect 340f; Mertect lsp; Metasol TK 10; Metasol TK 100; Mintesol; Mintezol; Minzolum; Mycozol; Nemacin; Nemapan; Omnizole; Ormogal; Polival; RPH; Sanaizol 100; Sistesan; Storite; TBDZ; TBZ; TBZ 6; TBZ 60W; Tebuzate; Tecto; Tecto 10P; Tecto 40F; Tecto 60; Tecto B; Tecto rph; Testo; Thiaben; Thiabendazol; Thiabendole; Thiabenzazole; Thiabenzole; Thibendole; Thibenzol; Thibenzole; Thibenzole 200; Thibenzole att; Thiprazole; Tiabenda; Tiabendazol; Tiabendazole; Tibimix 20; Tobaz; Top form wormer; Triasox; Tubazole


For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.


Thiabendazole is a fungicide and parasiticide. Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Thiabendazole is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Thiabendazole also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.

Mechanism of Action

The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.


Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.


Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.

Biotrnasformation / Drug Metabolism

Hepatic. Metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates.


Hypersensitivity to this product.

Thiabendazole is contraindicated as prophylactic treatment for pinworm infestation.

Drug Interactions

Thiabendazole may compete with other drugs, such as theophylline, for sites of metabolism in the liver, thus elevating the serum levels of such compounds to potentially toxic levels. Therefore, when concomitant use of thiabendazole and xanthine derivatives is anticipated, it may be necessary to monitor blood levels and/or reduce the dosage of such compounds. Such concomitant use should be administered under careful medical supervision.

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