Chemisty and Biological Activity
Chemical Formula
C22H24N2O8
Chemical Name
2-(amino-hydroxy-methylidene)-4-dimethylamino-6,10,11,12a-tetrahydroxy-6- methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
Chemical Structure
Molecular Weight
444.435 g/mol
Physical State
Solid
Melting Point
165oC
Water Solubility
231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))
Isoelectric Point
3.3
Organisms Affected
Enteric bacteria and other eubacteria
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | 30S ribosomal protein S4 - Escherichia coli | | Gene Name | rpsD | | Synonyms | 30S ribosomal protein S4 | | General Function | Translation, ribosomal structure and biogenesis | | Specific Function | Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase |
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