DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Active ingredient: Terbutaline - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Adrenergic beta-Agonists
  • Tocolytic Agents
  • Bronchodilator Agents
  • Sympathomimetic

Dosage Forms

  • Metered-dose (aerosol)
  • Powder
  • Tablets
  • IV injection
  • Subcutaneous injection

Brands / Synonyms

Brethaire; Brethine; Brican; Bricanyl; Bricar; Bricaril; Bricyn; Terbutalin; Terbutalina [Dcit]; Terbutaline; Terbutaline Sulfate; Terbutalino [Inn-Spanish]; Terbutalinum [Inn-Latin]

Indications

For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.

Pharmacology

Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Mechanism of Action

The pharmacologic effects of terbutaline are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Absorption

Not Available

Toxicity

Terbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Brethine is contraindicated in patients known to be hypersensitive to sympath-omimetic amines or any component of this drug product.

Drug Interactions

Drug Interactions:

The concomitant use of Terbutaline with other sympathomimetic agents is not recommended, since the combined
effect on the cardiovascular system may be deleterious to the patient.

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants:
Terbutaline should be administered with extreme caution to patients being treated with monoamine oxidase
inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, since the
action of terbutaline on the vascular system may be potentiated.

Beta-Blockers:
Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists,
such as Terbutaline, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma
should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis
after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking
agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although
they should be administered with caution.

Diuretics:
The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing
diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the
recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not
known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017