Brands, Medical Use, Clinical Data
- Powder for solution
- Solution (IV injection)
Brands / Synonyms
Alteplase; Reteplase; t- PA; t-plasminogen activator; Tissue-type plasminogen activator precursor; Tnkase; TNKase (Genentech Inc)
Tissue plasminogen activator (tPA). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
For treatment of myocardial infarction and lysis of intracoronary emboli
Cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
Mechanism of Action
TNKase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.
Biotrnasformation / Drug Metabolism