Brands, Medical Use, Clinical Data
Brands / Synonyms
Methazolastone; Temodal; Temodar; Temozolamide; Temozolodida [Spanish]; Temozolomide [Ban:Inn]; Temozolomidum [Latin]
For the treatment of adult patients diagnosed with anaplastic astrocytoma who have relapsed following chemotherapy
Temozolomide is an antineoplastic agent. It causes death of of rapidly replicating cells, especially malignant cells, leading to regression or slowed tumor growth.
Mechanism of Action
Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is due to alkylation of DNA at the O6 and N7 positions of guanine.
Rapid and complete absorption in the gastrointestinal tract
Biotrnasformation / Drug Metabolism
TEMODAR (temozolomide) Capsules are contraindicated in patients who have a history of hypersensitivity reaction to
any of its components. TEMODAR is also contraindicated in patients who have a history of hypersensitivity to DTIC,
since both drugs are metabolized to MTIC.
Administration of valproic acid decreases oral clearance of temozolomide by about 5%. The clinical implication of
this effect is not known.
Patients with Severe Hepatic or Renal Impairment
Caution should be exercised when TEMODAR Capsules are administered to patients with severe hepatic or renal