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Active ingredient: Tacrolimus - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C44H69NO12

Chemical Name

[3S- [3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]- 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19- dihydroxy-3- [2-(4-hydroxy-3-methoxycyclohexyl) -1-methylethenyl]-14, 16- dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2,1- c][1,4] oxaazacyclotricosine-1,7,20, 21(4H,23H)-tetrone, monohydrate

Chemical Structure

Molecular Weight

804.018 g/mol

Physical State

Solid

Melting Point

126 oC

Water Solubility

Insoluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target
NameFK506-binding protein 1A
Gene NameFKBP1A
SynonymsEC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase; 12 kDa FKBP; FKBP-12; Immunophilin FKBP12
General FunctionPosttranslational modification, protein turnover, chaperones
Specific FunctionMay play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Reactionpeptidylproline (omega=180) = peptidylproline (omega=0)

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