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Active ingredient: Sumatriptan - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name


Chemical Structure

Molecular Weight

295.402 g/mol

Physical State


Melting Point

169-171 oC

Water Solubility

21.4 mg/ml

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Monoamine oxidase A (MAO-A)

Primary Drug Target
Name5-HT-1D Receptor
Gene NameHTR1D
Synonyms5-hydroxytryptamine 1D receptor; 5-HT-1D; Serotonin receptor 1D; 5- HT-1D-alpha
Specific FunctionThis is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

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