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Active ingredient: Sulfinpyrazone - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Uricosuric Agents

Dosage Forms

  • 100-mg tablets and 200-mg capsules for oral administration

Brands / Synonyms

Anturan; Anturane; Anturanil; Anturano; Anturen; Anturidin; Apo-Sulfinpyrazone; Diphenylpyrazone; Enturan; Enturen; Novopyrazone; Sulfinpyrazine; Sulfinpyrazon; Sulfoxyphenylpyrazolidine; Sulphinpyrazone; Usaf Ge-13

Indications

For the treatment of gout and gouty arthritis.

Pharmacology

Sulfinpyrazone's pharmacologic activity is the potentiation of the urinary excretion of uric acid. It is useful for reducing the blood urate levels in patients with chronic tophaceous gout and acute intermittent gout, and for promoting the resorption of tophi.

Mechanism of Action

Not Available

Absorption

Not Available

Toxicity

Symptoms of overdose include nausea, vomiting, diarrhea, epigastric pain, ataxia, labored respiration, convulsions, coma. Possible symptoms, seen after overdosage with other pyrazolone derivatives: anemia, jaundice, and ulceration.

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Patients with an active peptic ulcer or symptoms of gastrointestinal inflammation or ulceration should not receive the drug.

The drug is contraindicated in patients with a history or the presence of:

1. Hypersensitivity to phenylbutazone or other pyrazoles

2. Blood dyacrasias

Drug Interactions

No information provided.

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