Brands, Medical Use, Clinical Data
- Anti-Infectives Agents, Local
- Anti-Infectives Agents, Urinary
- Anti-bacterial Agents
Brands / Synonyms
Acetocid; Acetosulfamin; Acetosulfamine; Ak-Sulf; Albamine; Albucid; Alesten; Avar Gel; Bleph-10; Bleph-10 Liquifilm; Blephamide; Cetamide; Clenia; FML-S; Formosulfacetamide; Gyne-Sulf; I-Sulfacet; Isopto Cetamide; Isopto-Cetamide; Klaron; N'-Acetylsulfanilamide; N-Acetylsulfanilamide; N-Acetylsulfanilamine; N-Sulfanilylacetamide; N-Sulphanilylacetamide; Oclucid; Ocusulf-10; Op-Sulfa 30; Ophthacet; Ophthel-S; Ovace Plus Shampoo; P-Aminobenzenesulfonacetamide; P-Aminobenzenesulfonoacetamide; Plexion Cleanser; Region; Rosanil; Sebizon; Sodium Sulamyd; Sodium Sulfacetamide; Steramide; Steri-Units Sulfacetamide; Sulamyd; Sulf-10; Sulf-15; Sulfacel-15; Sulfacet; Sulfacetamide and Prednisolone; Sulfacetamide Sodium; Sulfacetamide Sodium Anhydrous; Sulfacetamide Sodium Usp; Sulfacetimide; Sulfacyl; Sulfair; Sulfair 10; Sulfair 15; Sulfair Forte; Sulfair-15; Sulfamide; Sulfanilacetamide; Sulfanilazetamid; Sulfatol C; Sulfex; Sulphacetamide; Sulphacetamide Sodium; Sulphasil; Sulten-10; Sultrin; Triple Sulfa; Trysul; Urosulfon; Urosulfone; Vagilia
For the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis.
Sulfacetamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Mechanism of Action
Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth (according to the Woods-Fildes theory). The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Oral LD50 Mouse : 16500 mg/kg. Side effects include moderate to severe erythema (redness) and moderate edema (raised kin), nausea, vomiting, headache, dizziness, and tiredness. Higher exposure causes unconsciousness.
Biotrnasformation / Drug Metabolism
Hypersensitivity to sulfonamides or to any ingredient of this preparation.
Sulfacetamide preparations are incompatible with silver preparations.