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Active ingredient: Streptomycin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C21H39N7O12

Chemical Name

5-(2,4-diguanidino-3,5,6-trihydroxy-cyclohexoxy)-4-[4,5-dihydroxy-6- (hydroxymethyl)-3-methylamino-tetrahydropyran-2-yl]oxy-3-hydroxy-2-methyl- tetrahydrofuran-3-carbaldehyde

Chemical Structure

Molecular Weight

581.574 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Enteric bacteria and other eubacteria

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
Name30S ribosomal protein S12
Gene NamerpsL
Synonyms30S ribosomal protein S12
General FunctionTranslation, ribosomal structure and biogenesis
Specific FunctionCryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit

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