Chemisty and Biological Activity
Chemical Formula
C10H12N2O4
Chemical Name
1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4- dione
Chemical Structure
Molecular Weight
224.213 g/mol
Physical State
Solid
Melting Point
159 - 160 oC
Water Solubility
5-10 g/100 mL at 21 oC
Isoelectric Point
Not Available
Organisms Affected
Human immunodeficiency virus
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | HIV-1 Reverse Transcriptase | | Gene Name | POL | | Synonyms | Pol polyprotein [Contains: Protease; Retropepsin; EC 3.4.23.16; Reverse transcriptase/ribonuclease H; EC 2.7.7.49; EC 3.1.26.4; RT; Integrase; IN] | | Specific Function | During replicative cycle of retroviruses, the reverse- transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase | | Reaction | Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro |
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