Active ingredient: Spironolactone - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C24H32O4S

Chemical Name

Not Available

Chemical Structure

Molecular Weight

416.574 g/mol

Physical State

Solid

Melting Point

134.5 oC

Water Solubility

Practically insoluble (22 mg/L)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	Type-1 angiotensin II Receptor (AT1)
Gene Name	AGTR1
Synonyms	Type-1 angiotensin II receptor; AT1; AT1AR
Specific Function	Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system