Brands, Medical Use, Clinical Data
- Sterile powder for injectable suspension
Brands / Synonyms
Actinospectacin; Actinospectacina [Italian]; Antibiotic 2233wp; Espectinomicina; Espectinomicina [INN-Spanish]; SCM; Spectam; Spectinomicina [Italian]; Spectinomycin Di HCl; Spectinomycin HCl/ Sulphate; Spectinomycine [INN-French]; Spectinomycinum [INN-Latin]; Togamycin; Trobicin; Trobicin
For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae.
Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.
Mechanism of Action
Spectinomycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bacteriostatic in its action.
Rapidly and almost completely absorbed after intramuscular injection.
Acute oral toxicity (LD50): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.
Biotrnasformation / Drug Metabolism
The use of TROBICIN Sterile Powder is contraindicated in patients previously found hypersensitive to
No specific information available.