Active ingredient: Spectinomycin - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

• Anti-Bacterial Agents

Dosage Forms

• Sterile powder for injectable suspension

Brands / Synonyms

Actinospectacin; Actinospectacina [Italian]; Antibiotic 2233wp; Espectinomicina; Espectinomicina [INN-Spanish]; SCM; Spectam; Spectinomicina [Italian]; Spectinomycin Di HCl; Spectinomycin HCl/ Sulphate; Spectinomycine [INN-French]; Spectinomycinum [INN-Latin]; Togamycin; Trobicin; Trobicin

Indications

For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae.

Pharmacology

Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.

Mechanism of Action

Spectinomycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bacteriostatic in its action.

Absorption

Rapidly and almost completely absorbed after intramuscular injection.

Toxicity

Acute oral toxicity (LD₅₀): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

The use of TROBICIN Sterile Powder is contraindicated in patients previously found hypersensitive to it.

Drug Interactions

No specific information available.