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Active ingredient: Sorafenib - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C21H16ClF3N4O3

Chemical Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl- pyridine-2-carboxamide

Chemical Structure

Molecular Weight

464.825 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Practically insoluble (as tosylate salt)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4; UGT1A9

Primary Drug Target
NameB-Raf proto-oncogene serine/threonine-protein kinase
Gene NameBRAF
SynonymsEC 2.7.1.37; p94; v-Raf murine sarcoma viral oncogene homolog B1
General FunctionGeneral function prediction only
Specific FunctionInvolved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron
Pathwaymap04070 Phosphatidylinositol signaling system
ReactionATP + a protein = ADP + a phosphoprotein

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