Chemisty and Biological Activity
Chemical Formula
C21H16ClF3N4O3
Chemical Name
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl- pyridine-2-carboxamide
Chemical Structure
Molecular Weight
464.825 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Practically insoluble (as tosylate salt)
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4; UGT1A9
Primary Drug Target
Name | B-Raf proto-oncogene serine/threonine-protein kinase | Gene Name | BRAF | Synonyms | EC 2.7.1.37; p94; v-Raf murine sarcoma viral oncogene homolog B1 | General Function | General function prediction only | Specific Function | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron | Pathway | map04070 Phosphatidylinositol signaling system | Reaction | ATP + a protein = ADP + a phosphoprotein |
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