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Active ingredient: Simvastatin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C25H38O5

Chemical Name

[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7- dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate

Chemical Structure

Molecular Weight

418.566 g/mol

Physical State

Solid

Melting Point

135-138oC

Water Solubility

0.76 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target
NameHMG-CoA Reductase
Gene NameHMGCR
Synonyms3-hydroxy-3-methylglutaryl-coenzyme A reductase; EC 1.1.1.34; HMG-CoA reductase
General FunctionLipid transport and metabolism
Specific FunctionThis transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis
Pathwaymap00100 Biosynthesis of steroids
Reaction(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

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