Chemisty and Biological Activity
Chemical Formula
C25H38O5
Chemical Name
[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7- dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
Chemical Structure
Molecular Weight
418.566 g/mol
Physical State
Solid
Melting Point
135-138oC
Water Solubility
0.76 mg/L
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
Name | HMG-CoA Reductase | Gene Name | HMGCR | Synonyms | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; EC 1.1.1.34; HMG-CoA reductase | General Function | Lipid transport and metabolism | Specific Function | This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis | Pathway | map00100 Biosynthesis of steroids | Reaction | (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ |
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