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Active ingredient: Sibutramine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C17H26ClN

Chemical Name

1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine

Chemical Structure

Molecular Weight

279.848 g/mol

Physical State

Solid

Melting Point

191-192 oC

Water Solubility

2.9 mg/mL (in pH 5.2 water)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target
NameSodium-dependent serotonin re-uptake pump
Gene NameSLC6A4
SynonymsSodium-dependent serotonin transporter; 5HT transporter; 5HTT
General FunctionTransport activities
Specific FunctionTerminates the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals

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