Brands, Medical Use, Clinical Data
- Hypnotics and Sedatives
Brands / Synonyms
(+/-)-Secobarbital; Barbosec; Bipanal; Bipinal sodium; DEA No. 2315; DEA No. 2316; Evronal; Evronal Sodium; Evrronal; Hypotrol; Hyptran; Imesonal; Immenoctal; Immenox; Meballymal; Meballymal sodium; Meballymalum; Novosecobarb; Pramil; Quinalbarbital; Quinalbarbitone; Quinalbarbitone sodium; Quinalspan; Sebar; Seco 8; Secobarbital (USP); Secobarbital Sodium; Secobarbital suppository dosage form; Secobarbital [USAN:INN]; Secobarbitale [DCIT]; Secobarbitalum [INN-Latin]; Secobarbitone; Seconal; Seconal (TN); Seconal Sodium; Sedutain; Seotal; Sodium quinalbarbitone; Sodium Secobarbital; Sodium Seconal; Somosal; Synate; Trisomnin
For the Short-term treatment of intractable insomnia for patients habituated to barbiturates
Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
Mechanism of Action
Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Biotrnasformation / Drug Metabolism
Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers.