Brands, Medical Use, Clinical Data
Drug Category
- Mydriatics
- Adjuvants
- Antimuscarinics
- Antispasmodics
Dosage Forms
Brands / Synonyms
Atrochin; Atroquin; Atroscine Hydrobromide; Beldavrin; Buscopan; Epoxytropine Tropate; Euscopol; Hydroscine Hydrobromide; Hyocine F Hydrobromide; Hyosceine; Hyoscine; Hyoscine Bromide; Hyoscine Hydrobromide; Hyoscyine Hydrobromide; Hyosol; Hysco; Isopto Hyoscine; Isoscopil; Kwells; L-Hyoscine Hydrobromide; L-Scopolamine; Methscopolamine Bromide; Oscine; Pamine; PB Hyos; Scop; Scopamin; Scopine Tropate; Scopoderm-Tts; Scopolamine; Scopolamine Bromide; Scopolamine Hydrobromide; Scopolamine Hydrobromide Trihydrate; Scopolamine Hyoscine; Scopolaminhydrobromid; Scopolaminium Bromide; Scopolammonium Bromide; Scopos; SEE; Sereen; Skopolamin; Tranaxine; Transcop; Transderm Scop; Transderm-Scop; Transderm-V; Triptone; Tropic Acid, Ester with Scopine
Indications
For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.
Pharmacology
Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopolamine has many uses including the prevention of motion sickness. It is not clear how Scopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Scopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Scopolamine also may work directly on the vomiting center. Scopolamine must be taken before the onset of motion sickness to be effective.
Mechanism of Action
Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Transderm Scop is contraindicated in persons who are hypersensitive to the drug scopolamine or to other belladonna
alkaloids, or to any ingredient or component in the formulation or delivery system, or in patients with angle-closure
(narrow angle) glaucoma.
Drug Interactions
The absorption of oral medications may be decreased during the concurrent use of scopolamine because of decreased
gastric motility and delayed gastric emptying.
Scopolamine should be used with care in patients taking other drugs that are capable of causing CNS effects such
as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having
anticholinergic properties; e.g., other belladonna alkaloids, antihistamines (including meclizine), tricyclic
antidepressants, and muscle relaxants.
Laboratory Test Interactions
Scopolamine will interfere with the gastric secretion test.
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