Brands, Medical Use, Clinical Data
Brands / Synonyms
OncoScint; OncoScint (Cytogen Corp, Lonza Biologics)
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors.
For diagnosis of extrahepatic malignant cancers
Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors
Mechanism of Action
Binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
Biotrnasformation / Drug Metabolism
Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production