Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
Brands / Synonyms
OncoScint; OncoScint (Cytogen Corp, Lonza Biologics)
Description
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors.
Indications
For diagnosis of extrahepatic malignant cancers
Pharmacology
Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors
Mechanism of Action
Binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production
Contraindications
Not Available
Drug Interactions
Not Available
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