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Active ingredient: Rocuronium - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Neuromuscular Nondepolarizing Agents
  • Skeletal Muscle Relaxants

Dosage Forms

  • Solution (for intravenous injection containing 10mg rocuronium bromide/mL solution)

Brands / Synonyms

Rocuronium bromide; Zemuron; Zemuron


For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.


Rocuronium is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration

Mechanism of Action

Rocuronium competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.


Not Available


No cases of significant accidental or intentional overdose have been reported. Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.

Biotrnasformation / Drug Metabolism

Not Available


ZEMURON® (rocuronium bromide) Injection is contraindicated in patients known to have hypersensitivity to rocuronium bromide.

Drug Interactions

Drug Interactions:   The use of ZEMURON® (rocuronium bromide) Injection before succinylcholine, for the purpose of attenuating some of the side effects of succinylcholine, has not been studied.

If ZEMURON® is administered following administration of succinylcholine, it should not be given until recovery from succinylcholine has been observed. The median duration of action of ZEMURON® 0.6 mg/kg administered after a 1 mg/kg dose of succinylcholine when T 1 returned to 75% of control was 36 minutes (range 14-57, n=12) vs. 28 minutes (17-51, n=12) without succinylcholine.

There are no controlled studies documenting the use of ZEMURON® before or after other nondepolarizing muscle relaxants. Interactions have been observed when other nondepolarizing muscle relaxants have been administered in succession.

Drug/Laboratory Test Interactions:   None known.

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