Brands, Medical Use, Clinical Data
Drug Category
- Neuromuscular Nondepolarizing Agents
- Skeletal Muscle Relaxants
Dosage Forms
- Solution (for intravenous injection containing 10mg rocuronium bromide/mL solution)
Brands / Synonyms
Rocuronium bromide; Zemuron; Zemuron
Indications
For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Pharmacology
Rocuronium is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration
Mechanism of Action
Rocuronium competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.
Absorption
Not Available
Toxicity
No cases of significant accidental or intentional overdose have been reported. Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
ZEMURON® (rocuronium bromide) Injection is contraindicated in patients known to have hypersensitivity to
rocuronium bromide.
Drug Interactions
Drug Interactions: The use of ZEMURON® (rocuronium bromide) Injection before
succinylcholine, for the purpose of attenuating some of the side effects of succinylcholine, has not been
studied.
If ZEMURON® is administered following administration of succinylcholine, it should not be given until recovery
from succinylcholine has been observed. The median duration of action of ZEMURON® 0.6 mg/kg administered after a
1 mg/kg dose of succinylcholine when T 1 returned to 75% of control was 36 minutes (range 14-57, n=12)
vs. 28 minutes (17-51, n=12) without succinylcholine.
There are no controlled studies documenting the use of ZEMURON® before or after other nondepolarizing muscle
relaxants. Interactions have been observed when other nondepolarizing muscle relaxants have been administered in
succession.
Drug/Laboratory Test Interactions: None known.
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