Brands, Medical Use, Clinical Data
Drug Category
- Anti-inflammatory agents
- Corticosteroids
Dosage Forms
- Drops (10mg rimexolone/mL solution)
Brands / Synonyms
Vexol
Indications
For the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis.
Pharmacology
Rimexolone is a glucocorticoid corticosteroid for systemic use. Corticosteroids suppress the inflammatory response to a variety of inciting agents of a mechanical, chemical, or immunological nature. They inhibit edema, cellular infiltration, capillary dilatation, fibroblastic proliferation, deposition of collagen and scar formation associated with inflammation.
Mechanism of Action
Betamethasone is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes.
Absorption
Systemically absorbed.
Toxicity
Symptoms of overdose include retinal toxicity, glaucoma, and subcapsular cataract.
Biotrnasformation / Drug Metabolism
Undergoes extensive metabolism. Following intravenous administration of radiolabeled rimexolone in rats, more than 80% of the dose was excreted in the feces as rimexolone and metabolites. Metabolites have been shown to be either less active than rimexolone or inactive in human glucocorticoid receptor binding assays.
Contraindications
VEXOL® 1% is contraindicated in epithelial herpes simplex keratitis (dendritic keratitis), vaccinia,
varicella, and most other viral diseases of the cornea and conjunctiva; mycobacterial infection of the eye; fungal
diseases of the eye; acute purulent untreated infections which, like other diseases caused by microorganisms, may be
masked or enhanced by the presence of the steroid; and in those persons with hypersensitivity to any component of the
formulation.
Drug Interactions
Not Available
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