Chemisty and Biological Activity
Chemical Formula
C43H58N4O12
Chemical Name
{2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,} 1-b\]furan-1,11(2H)- dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2, 4,12,16,18,20, {22- heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-,} 21-acetate
Chemical Structure
Molecular Weight
822.94 g/mol
Physical State
Solid
Melting Point
183 oC
Water Solubility
1.4 mg/mL
Isoelectric Point
Not Available
Organisms Affected
Mycobacteria and a variety of other gram negative and gram postivie bacteria
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
| Name | DNA-directed RNA polymerase beta chain | | Gene Name | rpoB | | Synonyms | EC 2.7.7.6; RNAP beta subunit; Transcriptase beta chain; RNA polymerase beta subunit | | General Function | Transcription | | Specific Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates | | Pathway | map00230 Purine metabolism
map00240 Pyrimidine metabolism
map03020 RNA polymerase | | Reaction | nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) |
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