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Active ingredient: Ribavirin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C8H12N4O5

Chemical Name

1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole- 3-carboxamide

Chemical Structure

Molecular Weight

244.205 g/mol

Physical State

Solid

Melting Point

174-176 oC

Water Solubility

142 mg/mL (max, at 25°C)

Isoelectric Point

Not Available

Organisms Affected

Hepatitis C virus, RSV and other RNA/DNA viruses

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
Nameadenosine kinase
Gene NameADK
SynonymsAdenosine kinase; EC 2.7.1.20; AK; Adenosine 5'-phosphotransferase
General FunctionCarbohydrate transport and metabolism
Specific FunctionATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides
Pathwaymap00230 Purine metabolism
ReactionATP + adenosine = ADP + AMP

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