Active ingredient: Reserpine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

• Antipsychotics
• Antihypertensive Agents
• Peripheral Adrenergic Inhibitors

Dosage Forms

• Tablets

Brands / Synonyms

Cam-Ap-Es; Demi-Regroton; Diupres; Diupres-250; Diupres-500; Diutensen-R; Dralserp; Hiserpia; Hydrap-ES; Hydromox R; Hydroserpine Plus (R-H-H); Metatensin #2; Metatensin #4; Naquival; Novoreserpine; Rau-Sed; Regroton; Renese-R; Reserfia; Reserpine; Salutensin; Salutensin-Demi; Sandril; Ser-A-Gen; SER-AP-ES; Serpalan; Serpalan (TN); Serpanray; Serpasil; Serpasil-Apresoline; Serpasil-Esidrix #1; Serpasil-Esidrix #2; Serpate; Serpivite; Unipres

Indications

Foe the treatment of hypertension

Pharmacology

Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.

Mechanism of Action

Reserpine's mechanism of action is through inhibition of the ATP/Mg²⁺ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.

Absorption

Not Available

Toxicity

Possible human carcinogen. May cause reproductive harm. ORL-RAT LD₅₀ 420 mg/kg; IPR-RAT LD₅₀ 44 mg/kg; IVN-RAT LD₅₀ 15 mg/kg; ORL-MUS LD₅₀ 200 mg/kg; SCU-MUS LD₅₀ 52 mg/kg; IPR-RBT LD₅₀ 7 mg/kg

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available