Chemisty and Biological Activity
Chemical Formula
C27H36N2O4
Chemical Name
2-ethoxy-4-[[3-methyl-1-[2-(1-piperidyl)phenyl]- butyl]carbamoylmethyl]benzoic acid
Chemical Structure
Molecular Weight
452.586 g/mol
Physical State
Solid
Melting Point
130-131 oC
Water Solubility
Not Available
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP2C8
Primary Drug Target
Name | ATP-sensitive inward rectifier potassium channel 1 | Gene Name | KCNJ1 | Synonyms | ATP-sensitive inward rectifier potassium channel 1; Potassium channel, inwardly rectifying, subfamily J, member 1; ATP-regulated potassium channel ROM-K; Kir1.1 | Specific Function | In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendancy to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium |
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