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Active ingredient: Repaglinide - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

2-ethoxy-4-[[3-methyl-1-[2-(1-piperidyl)phenyl]- butyl]carbamoylmethyl]benzoic acid

Chemical Structure

Molecular Weight

452.586 g/mol

Physical State


Melting Point

130-131 oC

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
NameATP-sensitive inward rectifier potassium channel 1
Gene NameKCNJ1
SynonymsATP-sensitive inward rectifier potassium channel 1; Potassium channel, inwardly rectifying, subfamily J, member 1; ATP-regulated potassium channel ROM-K; Kir1.1
Specific FunctionIn the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendancy to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium

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