Brands, Medical Use, Clinical Data
- Anti-Ulcer Agents
- Histamine H2 Antagonists
Brands / Synonyms
Alquen; Alter-H2; Alvidina; Apo-Ranitidin; Artomil; Azuranit; Coralen [inj.]; Digestosan; Ergan; Esofex; Fendibina; Gastrial; Gastridina; Gastrolav; Gastrosedol; Kuracid; Label; Lake; Logat; Melfax; Microtid; Mideran; Neugal; Noctone; Noktome; Normon; Novo-Radinine; Nu-Ranit; Pep-Rani; Ptinolin; Quadrin; Quantor [inj.]; Radin; RAN; Ran H2; Ran Lich; Rani 2; Rani AbZ; Rani-BASF; Rani-nerton; Rani-Puren; Rani-Q; Rani-Sanorania; Raniben; Raniberl; Raniberta; Ranibloc; Ranic; Ranicux; Ranidil; Ranidin; Ranidine; Ranidura; Ranifur [inj.]; Ranigasan; Ranigast; Ranigen; Ranilonga; Ranimerck; Raniogas; Raniplex; Ranisan; Ranitab; Ranitic; Ranitidin; Ranitidin 1A Pharma; Ranitidin AL; Ranitidin Arcana; Ranitidin Atid; Ranitidin AWD; Ranitidin Basics; Ranitidin Duncan; Ranitidin Dyna; Ranitidin Helvepharm; Ranitidin Heumann; Ranitidin Hexal; Ranitidin Merck; Ranitidin Millet; Ranitidin NM; Ranitidin Normon; Ranitidin PB; Ranitidin Stada; Ranitidin von ct; Ranitidin-Cophar; Ranitidin-Isis; Ranitidin-ratiopharm; Ranitidina predilu Grif; Ranitidina Tamarang; Ranitidine; Ranitidine Base; Ranitidine HCL; Ranitidine HCl (Form I And Form Ii); Ranitidine hydrochloride; Ranitidine hydrochloride (JP14/USP); Ranitidine hydrochloride [JAN]; Ranitiget; Ranitin; Ranitine; Ranobel; Rantacid; Rantidine HCL; Ranuber; Raticina; Regalil; Renatac; Rozon; Rubiulcer; Santanol; Serviradine; Sostril; Tanidina; Taural; Terposen; Toriol; Trigger; Ulcecur; Ulcex; Ulcirex; Ulcodin; Ulcolind Rani; Ulcosan; Ulsaven; Ultidine; Viserul; Zandid; Zantac; Zantac 150; Zantac 75; Zantac In Plastic Container; Zantarac; Zantic
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Mechanism of Action
The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.
Approximately 50% bioavailability orally.
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Biotrnasformation / Drug Metabolism
Hepatic. Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites, accounting for approximately 4%, 1%, and 1% of the dose, respectively.
TRITEC is contraindicated in patients known to have hypersensitivity to ranitidine bismuth citrate or any of its
For information on clarithromycin contraindications, see clarithromycin package insert.
Coadministration of TRITEC with clarithromycin resulted in increased plasma ranitidine concentrations (57%),
increased plasma bismuth trough concentrations (48%), and increased 14- hydroxy- clarithromycin plasma concentrations
(31%). Coadministration with aspirin results in a slight decrease in the rate of salicylate absorption that is
clinically unimportant. Coadministration with a high dose of antacid (170 mEq) results in a 28% decrease in plasma
concentrations of ranitidine and may decrease plasma concentrations of bismuth from TRITEC. These effects are
For information on drug interactions associated with ranitidine, refer to the ZANTAC ® package insert.