Brands, Medical Use, Clinical Data
- Anesthetics, Intravenous
- Free Radical Scavengers
- Hypnotics and Sedatives
Brands / Synonyms
Diisopropylphenol; Diprivan; Disoprivan; Disoprofol; Rapinovet
Used for both induction and/or maintenance of anesthesia.
Propofol a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. Intravenous injection of a therapeutic dose of propofol produces hypnosis rapidly with minimal excitation, usually within 40 seconds from the start of an injection (the time for one arm-brain circulation).
Mechanism of Action
The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid(GABA) through GABA-A receptors.
Biotrnasformation / Drug Metabolism
DIPRIVAN Injectable Emulsion is contraindicated in patients with a known hypersensitivity to DIPRIVAN Injectable
Emulsion or its components, or when general anesthesia or sedation are contraindicated.
The induction dose requirements of DIPRIVAN Injectable Emulsion may be reduced in patients with intramuscular or
intravenous premedication, particularly with narcotics (eg, morphine, meperidine, and fentanyl, etc.) and
combinations of opioids and sedatives (eg, benzodiazepines, barbiturates, chloral hydrate, droperidol, etc.). These
agents may increase the anesthetic or sedative effects of DIPRIVAN Injectable Emulsion and may also result in more
pronounced decreases in systolic, diastolic, and mean arterial pressures and cardiac output.
During maintenance of anesthesia or sedation, the rate of DIPRIVAN Injectable Emulsion administration should be
adjusted according to the desired level of anesthesia or sedation and may be reduced in the presence of supplemental
analgesic agents (eg, nitrous oxide or opioids). The concurrent administration of potent inhalational agents (eg,
isoflurane, enflurane, and halothane) during maintenance with DIPRIVAN Injectable Emulsion has not been extensively
evaluated. These inhalational agents can also be expected to increase the anesthetic or sedative and
cardiorespiratory effects of DIPRIVAN Injectable Emulsion.
DIPRIVAN Injectable Emulsion does not cause a clinically significant change in onset, intensity, or duration of
action of the commonly used neuromuscular blocking agents (eg, succinylcholine and nondepolarizing muscle
No significant adverse interactions with commonly used premedications or drugs used during anesthesia or sedation
(including a range of muscle relaxants, inhalational agents, analgesic agents, and local anesthetic agents) have been