Active ingredient: Promethazine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C17H20N2S

Chemical Name

N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine

Chemical Structure

Molecular Weight

284.42 g/mol

Physical State

Solid

Melting Point

60oC

Water Solubility

Freely soluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2D6

Primary Drug Target

Name	D(2) Dopamine Receptor
Gene Name	DRD2
Synonyms	D(2 dopamine receptor; Dopamine D2 receptor
General Function	Receptor activity and cell communication
Specific Function	This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase