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Active ingredient: Primidone - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anticonvulsants
  • Barbiturates

Dosage Forms

  • Tablet
  • Chewable tablets
  • Oral suspension

Brands / Synonyms

Apo-Primidone; Cyral; Desoxyphenobarbitone; Hexadiona; Hexamidine; Lepimidin; Lepsiral; Liskantin; Majsolin; Medi-Pets; Midone; Milepsin; Misodine; Misolyne; Mizodin; Mizolin; Myidone; Mylepsin; Mylepsinum; Mysedon; Mysoline; Neurosyn; Pms Primidone; Prilepsin; Primacione; Primaclone; Primacone; Primakton; Primidon; Primidone; Primidone Methanol Solution; Primoline; Prysoline; Pyrimidone "Medi-Pets"; Pyrimidone Medi-Pets; Resimatil; Sertan


For the treatment of epilepsy


Primidone is a barbiturate with anticonvulsant properties. Primidone, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Primidone raises electro- or chemoshock seizure thresholds or alters seizure patterns in experimental animals. Primidone per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). In addition to its anticonvulsant activity, Primidone potentiates that of phenobarbital in experimental animals.

Mechanism of Action

Primidone is a GABA receptor agonist. The mechanism of Primidone's antiepileptic action is not known.


90 to 100%


Not Available

Biotrnasformation / Drug Metabolism



Primidone is contraindicated in:

1) patients with porphyria

2) patients who are hypersensitive to phenobarbital .

Drug Interactions

No information provided.

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