Brands, Medical Use, Clinical Data
Drug Category
- Anticonvulsants
- Barbiturates
Dosage Forms
- Tablet
- Chewable tablets
- Oral suspension
Brands / Synonyms
Apo-Primidone; Cyral; Desoxyphenobarbitone; Hexadiona; Hexamidine; Lepimidin; Lepsiral; Liskantin; Majsolin; Medi-Pets; Midone; Milepsin; Misodine; Misolyne; Mizodin; Mizolin; Myidone; Mylepsin; Mylepsinum; Mysedon; Mysoline; Neurosyn; Pms Primidone; Prilepsin; Primacione; Primaclone; Primacone; Primakton; Primidon; Primidone; Primidone Methanol Solution; Primoline; Prysoline; Pyrimidone "Medi-Pets"; Pyrimidone Medi-Pets; Resimatil; Sertan
Indications
For the treatment of epilepsy
Pharmacology
Primidone is a barbiturate with anticonvulsant properties. Primidone, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Primidone raises electro- or chemoshock seizure thresholds or alters seizure patterns in experimental animals. Primidone per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). In addition to its anticonvulsant activity, Primidone potentiates that of phenobarbital in experimental animals.
Mechanism of Action
Primidone is a GABA receptor agonist. The mechanism of Primidone's antiepileptic action is not known.
Absorption
90 to 100%
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Hepatic
Contraindications
Primidone is contraindicated in:
1) patients with porphyria
2) patients who are hypersensitive to phenobarbital .
Drug Interactions
No information provided.
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