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Active ingredient: Pregabalin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C8H17NO2

Chemical Name

3-(aminomethyl)-5-methyl-hexanoic acid

Chemical Structure

Molecular Weight

159.226 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

4.2 (pKa1); 10.6(pKa2)

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameVoltage-dependent P/Q-type calcium channel alpha-1A subunit
Gene NameCACNA1A
SynonymsVoltage- gated calcium channel alpha subunit Cav2.1; Calcium channel, L type, alpha-1 polypeptide isoform 4; Brain calcium channel I; BI
Specific FunctionVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the "high-voltage activated" (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA)

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