Chemisty and Biological Activity
Chemical Formula
C8H17NO2
Chemical Name
3-(aminomethyl)-5-methyl-hexanoic acid
Chemical Structure
Molecular Weight
159.226 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Not Available
Isoelectric Point
4.2 (pKa1); 10.6(pKa2)
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name | Voltage-dependent P/Q-type calcium channel alpha-1A subunit | Gene Name | CACNA1A | Synonyms | Voltage- gated calcium channel alpha subunit Cav2.1; Calcium channel, L type, alpha-1 polypeptide isoform 4; Brain calcium channel I; BI | Specific Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the "high-voltage activated" (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA) |
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