Chemisty and Biological Activity
Chemical Formula
C21H26O5
Chemical Name
17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17- decahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
Chemical Structure
Molecular Weight
358.428 g/mol
Physical State
Solid
Melting Point
233 - 235 oC
Water Solubility
312 mg/L
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
| Name | Glucocorticoid receptor | | Gene Name | NR3C1 | | Synonyms | GR | | Specific Function | Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues |
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