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Active ingredient: Piroxicam - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

9-(hydroxy-pyridin-2-ylamino-methylidene)-8-methyl-7,7-dioxo-7$l^{6}-thia-8- azabicyclo[4.4.0]deca-1,3,5-trien-10-one

Chemical Structure

Molecular Weight

331.348 g/mol

Physical State


Melting Point

198-200 oC

Water Solubility

23 mg/L

Isoelectric Point


Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameProstaglandin G/H synthase 1 precursor
Gene NamePTGS1
SynonymsEC; Cyclooxygenase- 1; COX-1; Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1
Specific FunctionMay play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells
Pathwaymap00590 Prostaglandin and leukotriene metabolism
Reactionarachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

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