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Active ingredient: Pimozide - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2- one

Chemical Structure

Molecular Weight

461.546 g/mol

Physical State


Melting Point

214-218 oC

Water Solubility

10 mg/L

Isoelectric Point


Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
NameD(2) dopamine receptor
Gene NameDRD2
SynonymsDopamine D2 receptor
General FunctionSignal transduction and cell communication
Specific FunctionThis is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

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